What is BL-8040?
BL-8040 is a novel high-affinity antagonist of CXCR4, a chemokine receptor expressed on several hematopoietic as well as epithelial cancer cells. CXCR4 interacts with the chemokine SDF-1 or CXCL12; this interaction has been shown to be important in retention and quiescence of leukemia cells (mainly the leukemia stem cells) in the bone marrow (BM). Disrupting the CXCR4-CXCL12 interaction, therefore, may result in mobilization of leukemia cells into the peripheral circulation, sensitizing them to anti-cancer therapy.
According to the BioLineRx website, BL-8040 demonstrated an excellent safety profile, and was very effective in mobilization of hematopoietic stem cells and white blood cells to the peripheral circulation.
It will be interesting to see how the results of the trial turn out.
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